Microbiomics — the study of entire microbial genomes and their functions within an environment — is rapidly advancing from basic research into clinical translation and industrial application. From soil microbial ecology to the human gut microbiome, from environmental monitoring to disease diagnosis, microbiome research is reshaping multiple scientific disciplines.
109–1010 cells per gram
Each gram of soil hosts 109–1010 microbial cells — the most complex microbial habitat on Earth. Soil microbes drive carbon and nitrogen cycling, organic matter decomposition, and plant growth promotion, profoundly shaping global ecosystems. Soil samples are the richest source for studying environmental microbial diversity, soil health assessment, and agricultural optimization.
~100 trillion microbes
The human gut harbors approximately 100 trillion microbes with a gene pool roughly 150 times that of the human genome — often called the “second genome.” The gut microbiome is intimately linked to obesity, diabetes, cancer, and neurodegenerative diseases. Fecal samples serve as the primary window into gut microbiota research.
High-quality nucleic acid extraction is the foundation of microbiome research, yet soil and stool samples present extraction challenges far beyond those of routine specimens. These three barriers have long frustrated researchers:
Soil: Contains minerals, clay, plant debris, humic substances, and diverse microbial communities.
Stool: Contains bilirubin, bile salts, humic acids, plant-derived polysaccharides, and numerous soluble impurities.
These complex components make nucleic acid release and purification exceptionally difficult.
Humic acids, fulvic acids, and other humic substances share highly similar physicochemical properties with nucleic acids, readily co-precipitating during extraction. These compounds potently inhibit DNA polymerase activity, leading to PCR failure or severely degraded sequencing quality. Traditional extraction methods struggle to remove these inhibitors effectively.
Environmental microorganisms exhibit immense diversity in cell wall architecture: the thick peptidoglycan of Gram-positive bacteria, the chitin walls of fungi, and the extreme resistance of bacterial spores. A single lysis approach cannot achieve balanced disruption across all taxa, introducing significant community composition bias and incomplete coverage.
YALI BIOTECH leverages deep expertise across sample preservation, pre-treatment, nucleic acid extraction, and purification to offer a fully integrated product system for soil and stool nucleic acid extraction. Built on a “Preserve → Pre-Treat → Extract → Automate” workflow, it covers the entire journey from sampling to high-quality nucleic acids.
DNA 2 years RT
RNA 7 days RT
Patented beads
+ optimized lysis buffer
Column + Magnetic Bead
Dual Platform
Pure 32
Automated Extraction
Column-based method for small-to-medium throughput and budget-conscious labs. Magnetic bead method for high-sensitivity, high-throughput, and automated scenarios. One brand, both platforms.
A260/A230 > 1.9, with humic acid residues dramatically lower than traditional methods. Ensures downstream PCR and NGS are unimpeded by inhibitors.
Preservation tubes + extraction kits + automated extractor — the entire workflow from a single brand. Full compatibility guaranteed, with dedicated technical support throughout.
Actual sample validation data demonstrates consistent, publication-grade quality metrics.
YALI BIOTECH’s soil and stool nucleic acid extraction products power research across a broad spectrum of scientific disciplines.
Microbiome research is evolving toward single-cell resolution, real-time monitoring, and multi-omics integration. YALI BIOTECH is continuously investing in next-generation nucleic acid extraction technologies.
AI-powered automatic parameter optimization — sample type recognition, lysis time matching, elution volume recommendation — enabling one-click optimal extraction.
Microfluidic chip-based single-cell sorting and nucleic acid capture, providing front-end solutions for microbial single-cell genomics.
Portable, instrument-free rapid nucleic acid extraction devices, meeting field environmental monitoring and primary point-of-care testing demands.
Simultaneous extraction of DNA, RNA, proteins, and metabolites from a single sample, realizing the vision of “one sample, multi-dimensional data.”
YALI BIOTECH is a National High-Tech Enterprise integrating R&D, manufacturing, and sales, headquartered in Yangshan Science & Technology Park, Suzhou New District. The company focuses on the industrialization of molecular detection technologies, with hundreds of R&D reserves across sample preservation, nucleic acid extraction & purification, and molecular detection enzyme raw materials — delivering professional, high-performance products for life sciences, in-vitro diagnostics, biomedicine, health testing, and inspection & quarantine.
For soil and stool microbiome research, YALI BIOTECH delivers a uniquely comprehensive ecosystem: preservation tubes (YS21061/YS21062), column-based kits (YC22008-A/B), flagship magnetic bead kits (YM26011, YMR91011), and the Pure 32 automated extractor (MC-A-32-16) — a complete, compatible, and fully supported workflow from a single trusted brand.
YALI BIOTECH is on a mission to “make complex sample extraction simple and efficient.” With proprietary patented inhibitor removal technology, high-efficiency lysis systems, and a dual-platform strategy spanning column-based and magnetic bead methods, we provide full-process support — from sampling to extraction — for researchers in environmental science, agricultural research, clinical medicine, and food safety.
Whether you are pursuing fundamental microbial ecology or advancing clinical translational applications, YALI BIOTECH delivers tailored nucleic acid extraction solutions.
🌐 Learn more at www.yalibiotech.com
Soil and stool samples present three major challenges: (1) extremely complex composition including minerals, humic substances, bile salts, and polysaccharides; (2) severe PCR inhibitor interference from humic acids and fulvic acids that co-precipitate with nucleic acids; and (3) diverse microbial cell wall structures requiring different lysis strategies. YALI BIOTECH’s patented inhibitor removal technology and optimized lysis system address all three challenges, achieving A260/A230 ratios above 1.9.
YALI BIOTECH provides a complete workflow: sample preservation (YS21061 stool DNA preservation tube up to 2 years, YS21062 stool RNA preservation tube up to 7 days at room temperature), column-based extraction (YC22008-A optimized for NGS, YC22008-B optimized for PCR/qPCR), magnetic bead-based extraction (YM26011 flagship DNA kit with patented inhibitor removal, YMR91011 RNA kit), and the YALEPIC Pure 32 automated nucleic acid extraction platform (MC-A-32-16).
YALEPIC MagEVO stool & soil DNA extraction kit (YM26011) uses patented inhibitor removal technology with proprietary intellectual property formulations that selectively remove humic acids and fulvic acids. Combined with high-affinity silica magnetic beads achieving over 95% nucleic acid binding efficiency, the kit delivers A260/A230 ratios above 1.9 and meets the sensitivity requirements of ddPCR and low-input library preparation.
Yes. The YALEPIC MagEVO magnetic bead-based kits are automation-ready and work with the YALEPIC Pure 32 automated nucleic acid extractor as well as mainstream branded extraction instruments. The Pure 32 features intelligent operation with inter-well CV below 3%, anti-contamination design, and flexible compatibility with diverse sample types. A hospital case study reported 3× faster batch processing, handling over 100 samples per day.
For DNA: concentration 20–80 ng/μL (stool) and 10–50 ng/μL (soil), A260/A280 of 1.8–2.0, A260/A230 above 1.9, 16S PCR success rate above 98%, and qPCR amplification efficiency of 90–110%. For RNA: concentration 10–50 ng/μL (stool) and 5–30 ng/μL (soil), RIN value above 7.0, A260/A280 at least 1.9, and genomic DNA carryover below the RT-qPCR detection limit.
Production center: 4th floor, Building 9, Yangshan Science and Technology
Industrial Park,No. 8 Jinyan Road, Suzhou High-tech Zone
Marketing center: Pujiang High-tech Park, Minhang District, Shanghai
Copyright: 2026 YALI Biotech Co., Ltd.
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