YALEPIC^® Blood Cell-Free DNA Storage Tube

Regular EDTA blood collection tubes can only preserve blood samples for a short period (typically hours) and cannot effectively inhibit nucleated cell apoptosis. Over time, apoptotic cells release large amounts of genomic DNA into plasma, diluting the true cfDNA signal and affecting downstream detection sensitivity. YALEPIC cfDNA storage tubes contain specialized cell protectants that stabilize nucleated cells, prevent apoptosis and genomic DNA release, ensuring cfDNA concentration remains stable for up to 14 days.

YALEPIC cfDNA storage tubes are designed to extend the pre-analytical processing window. After blood collection, cfDNA can be stably preserved for up to 14 days at 4-37 degrees C, eliminating the need for immediate processing. This provides great convenience for cross-regional sample transport, multi-center clinical trials, and centralized sample processing.

Please collect blood to the exact volume marked on the tube – 5 ml for the 5 ml specification and 10 ml for the 10 ml specification. Over- or under-collection will disrupt the ratio of blood to protectant, potentially affecting cfDNA preservation. Insufficient volume may cause excessive protectant concentration affecting cells osmotically; excessive volume may result in insufficient protectant to fully inhibit nuclease activity and cell apoptosis.

Yes. After blood collection, immediately invert the tube gently 8-10 times to ensure thorough contact between blood and protectant. Proper mixing: rotate wrist 180 degrees completely, turning palm-inward to palm-outward in a smooth, steady motion. Avoid vigorous shaking to prevent hemolysis and blood cell damage. Delayed or insufficient mixing may result in uneven protectant distribution, potentially affecting preservation.

YALEPIC cfDNA storage tubes are primarily designed for stable preservation of cfDNA.

Whole blood from YALEPIC cfDNA storage tubes is processed to obtain plasma via standard plasma separation protocols. The separated plasma is compatible with most commercial cell-free DNA extraction kits, including but not limited to YALEPIC, Qiagen, Thermo, and other mainstream products. Extracted cfDNA can be directly used for downstream PCR, qPCR, digital PCR, NGS, and other high-sensitivity detection.

Glass offers excellent airtightness, chemical inertness, and biocompatibility, suitable for long-term storage and applications with strict storage requirements, but is heavier and breakable. PET plastic is lightweight with excellent shatter resistance, ideal for cold chain transport and air express, effectively reducing breakage during transport. Choose based on transport distance, storage duration, and logistics method.

Store unused tubes at 4-30 degrees C in a dry, dark environment. Avoid freezing and excessive heat. Use before the expiration date on the packaging – after expiration, vacuum and additive activity may decrease. Take appropriate insulation or protective measures when transporting unused tubes under extreme temperature conditions.

YALEPIC cfDNA storage tubes have CE-IVD certification or domestic NMPA registration.